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Methods and materials for imparting resistance to pheA feedback control
Methods and materials for imparting resistance to pheA feedback control
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机译:对pheA反馈控制产生抵抗力的方法和材料
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摘要
Disclosed are DNA sequences encoding deletion, substitution and/or addition analogs of the E. coli enzyme, chorismate mutase/prephenate dehydratase (CMPD). Preferred expression products include [des-Gln307, des-Ala308, des-Gly309, des-Ala310]CMPD; [Leu306]CMPD; [des-Thr?304, Lys305¿, des-Gln306]CMPD; and [Cys309]CMPD display enzymatic activity of the wild type enzyme but are more resistant to inhibition in the presence of phenylalanine.
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