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Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6

机译:海绵体抑菌素2,海绵体抑菌素3,海绵体抑素4和海绵体抑素6的分离和结构

摘要

A black Spongia sp. in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancer) growth inhibitors named spongistatin 2 and spongistatin 3. A bright colored Southwest Indian Ocean sponge Spirastrella spinispirulifera has also been found to contain related human cancer cell growth inhibitors named spongistatin 4 and spongistatin 6. A method of treating human cancer cells with spongistatin 1, spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 is also disclosed. The approximate mean GI.sub.50 of the disclosed compounds in the NCI cell line panel is about 10.sup.-10 . mu.g/ml.
机译:黑色的Spongia sp。在Porifera类中,Demospongiae被发现含有两种新的异常活跃的细胞(人类癌症)生长抑制剂,分别名为spongistatin 2和spongistatin3。一种鲜艳的西南印度洋海绵体Spirastrella spinispirulifera也被发现含有相关的人类癌细胞生长抑制剂。分别命名为海绵体抑素4和海绵体抑素6。还公开了一种用海绵体抑素1,海绵体抑素2,海绵体抑素3,海绵体抑素4和海绵体抑素6治疗人癌细胞的方法。 NCI细胞系中所公开化合物的近似平均GI 50为约10.-10。克/毫升

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