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Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6
Isolation and structure of spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6
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机译:海绵体抑菌素2,海绵体抑菌素3,海绵体抑素4和海绵体抑素6的分离和结构
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摘要
A black Spongia sp. in the Porifera class Demospongiae has been found to contain two new and exceptionally active cell (human cancer) growth inhibitors named spongistatin 2 and spongistatin 3. A bright colored Southwest Indian Ocean sponge Spirastrella spinispirulifera has also been found to contain related human cancer cell growth inhibitors named spongistatin 4 and spongistatin 6. A method of treating human cancer cells with spongistatin 1, spongistatin 2, spongistatin 3, spongistatin 4 and spongistatin 6 is also disclosed. The approximate mean GI.sub.50 of the disclosed compounds in the NCI cell line panel is about 10.sup.-10 . mu.g/ml.
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