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Method for the disinsertion of vitreous body by an enzyme which disrupts or degrades chondroitin sulfate proteoglycan
Method for the disinsertion of vitreous body by an enzyme which disrupts or degrades chondroitin sulfate proteoglycan
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机译：通过破坏或降解硫酸软骨素蛋白聚糖的酶分解玻璃体的方法
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摘要
A method for selectively and completely disinserting the ocular vitreous body, epiretinal membranes and/or fibrocellular membranes from the neural retina, ciliary epithelium and posterior lens surface of the mammalian eye as an adjunct to vitrectomy comprises administering to the eye an effective amount of a protease-free glycosaminoglycanase enzyme, such as chondroitinase ABC, adapted to disrupt and/or degrade chondroitin sulfate glycosaminoglycan/proteoglycan localized specifically to sites of vitreoretinal adhesion and thereby permit complete disinsertion of the vitreous body and/or epiretinal membranes.
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