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A device, in order to facilitate self-catheterisation in women, the combination of said device with a catheter and a device for positioning and measurement in the construction and selection of said self-cathetisation device.
A device, in order to facilitate self-catheterisation in women, the combination of said device with a catheter and a device for positioning and measurement in the construction and selection of said self-cathetisation device.
A muscarinic receptor antagonist, useful in treatingirritable bowel syndrome, of the formula:- --- (I)or a pharmaceutically acceptable salt thereof, wherein R1 is agroup of the formula:-orwhere Z and Z1 are each independently hydrogen, halo orC1-C4 alkyl;is -(CH2)2-, -CH=CH-, -CH2-S-, -CH2-O-, -S- or -O-;Y is a direct link, O or S;R2 and R3 are each independently C1-C4 alkyl or togetherrepresent -(CH2)p- where p is 2, 3, 4 or 5;R4 is H or C1-C4 alkyl;m is 1, 2 or 3, with the proviso that when m is 1, Y isa direct link;and R is a group of the formula:- , , or where either R5 and R6 are certain specified optionalsubstituents,or R5 and R6, when attached to adjacent carbon atoms,together represent a group of the formula -O(CH2)rO-where r is 1, 2 or 3, -O(CH2)2- or -(CH2)3-;R7 is H, C1-C4 alkyl or -CONH2;and R8 is H, C1-C4 alkyl or C1-C4 alkoxy.
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