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Monoclonal analogue bodies MZ versus Ganglioside GD, MZ producing cells and MZ containing agent.

机译：单克隆类似物MZ与神经节苷脂GD，产生MZ的细胞和含有MZ的试剂。

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摘要

Disclosed is a novel anti-ganglioside GD1a monoclonal antibody (MZ) which is capable of recognizing ganglioside GD1a but is practically incapable of recognizing GalCer, LacCer, Gb3, Gb4, GA1, GA2, GM1, GM2, GM3, GD1b, GT1b, GQ1b, Fuc-GM1, nLc4 and sialosyl nLc4; MZ-producing cells; an MZ-containing reagent; and a method for the detection or quantification of GD1a using the reagent, e.g., to diagnose cancer, systematic lupus erythematosus and diseases resulting from organic injury of the nervous system.

机译：公开了一种新型的抗神经节苷脂GD1a单克隆抗体（MZ），该抗体能够识别神经节苷脂GD1a，但实际上不能识别GalCer，LacCer，Gb3，Gb4，GA1，GA2，GM1，GM2，GM3，GD1b，GT1b，GQ1b， Fuc-GM1，nLc4和唾液酸基nLc4;产生MZ的细胞;含MZ的试剂;以及使用该试剂检测或定量GD1a的方法，例如，用于诊断癌症，系统性红斑狼疮和神经系统器质性损伤所致疾病。

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公开/公告号DE3850325D1

专利类型
公开/公告日1994-07-28

原文格式PDF
申请/专利权人 MITSUI TOATSU CHEMICALS INC. TOKIO/TOKYO JP;
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申请/专利号DE19883850325T
发明设计人 SHIMADA SHIZUO MOBARA-SHI CHIBA-KEN JP;IWATA DAIJI MOBARA-SHI CHIBA-KEN JP;SATO WAKAO CHIBA-SHI CHIBA-KEN JP;
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申请日1988-09-07
分类号C12P21/00;C12N5/00;C12N15/00;G01N33/564;G01N33/574;G01N33/577;
国家 DE
入库时间 2022-08-22 04:36:36

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