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PHENYLENE FURYL, AND THIENYL LEUKOTRIENE B_ ANALOGUES
PHENYLENE FURYL, AND THIENYL LEUKOTRIENE B_ ANALOGUES
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机译：苯甲醛和亚丁基白三烯B_模拟
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摘要
ABSTRACTThis invention related to leukotriene B4antagonists having the structureand the pharmaceutically acceptable addition salts thereof;wherein R1 is lower alkyl having 1-10 carbon atoms;or lower alkenyl or alkynyl having 2-10 carbon atoms; orlower alkadienyl having 3-10 carbon atoms; or loweralkadienyl or alkenynyl having 4-10 carbon atoms;wherein R2 and R3 are the same or different andrepresent hydrogen or lower alkyl having 1-6 carbon atoms;wherein X is CH=CH, S, or O;wherein Y is CH=CH or C?C;wherein Z is OR4 or NR5R6, and wherein R4represents H, lower alkyl having 1-6 carbon atoms, or apharmaceutically acceptable cation, and wherein R5 andR6 act independently and represent H or lower alkylhaving 1-6 carbon atoms, or R5 and R6 may act togetherwith N to form a cycloamine of the formula:wherein q is an integer from 2-5;wherein m and n are the same or different and either1 or 0; andwherein p is an integer from 1 to 5.
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