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Topical pharmaceutical compsn. - contg. crosslinked cationic polymer and has enhanced skin penetration effects

机译:外用药物组合。 -续交联的阳离子聚合物,并具有增强的皮肤渗透效果

摘要

A new topical pharmaceutical compsn. having enhanced penetration through the skin comprises (a) a safe and effective amt. of a pharmaceutical active; and (b) from 0.1-10.0% of a high molecular wt. crosslinked cationic polymer of the formula (A)l(B)m(C)n where the polymer contains a crosslinking agent, where (A) is dialkylaminoalkyl acrylate monomer or its quat. ammonium or acid addn. sa (B) is a dialkylaminoalkyl methacrylate monomer or its quat. ammonium or acid addn. sa (C) is acrylamide; l is an integer of 0 or greater; m is an integer of 1 or greater; n is an integer of 0 or greater.
机译:一种新的局部药物组合物。具有增强的渗透性的皮肤包括(a)安全有效的止痛药。药物活性成分; (b)高分子量的0.1-10.0%。式(A)1(B)m(C)n的交联阳离子聚合物,其中聚合物包含交联剂,其中(A)是丙烯酸二烷基氨基烷基酯单体或其季铵盐。铵或酸。盐; (B)是甲基丙烯酸二烷基氨基烷基烷基酯单体或其季铵盐。铵或酸。盐; (C)为丙烯酰胺; l为0或更大的整数; m为1以上的整数。 n为0或更大的整数。

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