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Process for labelling proteins and peptides by acylation of their alpha amino functional group by a reagent containing an activated carboxylic functional group
Process for labelling proteins and peptides by acylation of their alpha amino functional group by a reagent containing an activated carboxylic functional group
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机译:通过含有活化羧基官能团的试剂将其α氨基官能团酰化来标记蛋白质和肽的方法
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摘要
The subject of the invention is a process for the attachment of a labelling group onto a peptide, consisting in acylating the alpha amino functional group of the peptide by a labelling reagent containing an activated carboxylic functional group, at a pH of between about 7.5 and 5.5. The carboxylic functional group of the labelling reagent is advantageously activated in the form of an N-hydroxysuccinimide ester; the labelling reagent may be in particular the Bolton-Hunter reagent.
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