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Somatotropins with alterations in the alpha-helix 3 region, alpha-helix 2 region combinations thereof, and in combination with other mutations
Somatotropins with alterations in the alpha-helix 3 region, alpha-helix 2 region combinations thereof, and in combination with other mutations
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机译：生长激素在α-螺旋3区域，其α-螺旋2区域组合以及与其他突变的组合中发生改变
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摘要
The present invention relates to somatotropin analogues with amino acid changes in the α-helix 3 regions of said somatotropins, changes in the α-helix 2 regions, combinations thereof plus combinations with other changes to the native amino acid sequence of somatotropins. The resulting analogues are stable for formulation in sustained release formulations, while maintaining biological activity. Further, methods for conducting site-directed mutagenesis on DNA encoding proteins and/or polypeptides also are provided.
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