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NOVEL PROLYL ENDOPEPTIDASE INHIBITORS SNA-115 AND SNA-115T, PRODUCTION THEREOF, AND STRAIN WHICH PRODUCES SAID INHIBITORS

机译：新型脯氨酸内肽酶抑制剂SNA-115和SNA-115T，其生产以及产生所述抑制剂的菌株

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摘要

A prolyl endopeptidase inhibitor SNA-115, which is a peptide represented by C113H142N26O27. An SNA-115 producing bacterium belonging to Microbispora sp. A process for producing SNA-115 by culturing the SNA-115 producing bacterium. A prolyl endopeptidase inhibitor SNA-115T, which is a peptide represented by C113H144N26O28 and produced by hydrolyzing SNA-115 with trypsin. SNA-115 and SNA-115T have a prolyl endopeptidase inhibiting activity and are useful as an active ingredient for preventing and treating amnesia, acquired immunodeficiency syndrome (AIDS) and HIV diseases.

机译：脯氨酰内肽酶抑制剂SNA-115，它是由C113H142N26O27代表的肽。属于微双孢菌属的产生SNA-115的细菌。通过培养产生SNA-115的细菌来产生SNA-115的方法。脯氨酰内肽酶抑制剂SNA-115T，它是由C113H144N26O28代表的肽，通过用胰蛋白酶水解SNA-115产生。 SNA-115和SNA-115T具有脯氨酰内肽酶抑制活性，可用作预防和治疗健忘症，获得性免疫缺陷综合症（AIDS）和HIV疾病的有效成分。

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公开/公告号WO9300361A1

专利类型
公开/公告日1993-01-07

原文格式PDF
申请/专利权人 SNOW BRAND MILK PRODUCTS CO. LTD.;KIMURA KENICHI;KANOU FUMIKO;TAKAHASHI HIDETOSHI;KUROSAWA KAZUHIKO;YOSHIHAMA MAKOTO;
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申请/专利号WO1992JP00784
发明设计人 TAKAHASHI HIDETOSHI;KUROSAWA KAZUHIKO;YOSHIHAMA MAKOTO;KIMURA KENICHI;KANOU FUMIKO;
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申请日1992-06-19
分类号A61K38/00;C07K7/56;
国家 WO
入库时间 2022-08-22 05:07:31

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