首页> 外国专利> Murine monoclonal antibody which is directed against human breast cancer cells, murine x murine hybridoma cell which produces such an antibody, the immunotoxin which comprises such an antibody, murine monoclone antibody which comprises a label, and process for destroying human breast cancer cells in vitro and for diagnosing human breast cancer cells

Murine monoclonal antibody which is directed against human breast cancer cells, murine x murine hybridoma cell which produces such an antibody, the immunotoxin which comprises such an antibody, murine monoclone antibody which comprises a label, and process for destroying human breast cancer cells in vitro and for diagnosing human breast cancer cells

机译:针对人乳腺癌细胞的鼠单克隆抗体,产生该抗体的鼠类x鼠杂交瘤细胞,包含该抗体的免疫毒素,包含标记的鼠单克隆抗体以及在体外破坏人乳腺癌细胞的方法诊断人乳腺癌细胞

摘要

Murine monoclonal antibodies are prepared and characterized which bind selectively to human breast cancer cells, are IgGs or IgMs, and when conjugated to ricin A chain, exhibit a TCID 50% against at least one of MCF-7, CAMA-1, SKBR-3, or BT-20 cells of less than about 10 nM. Methods for diagnosing, monitoring, and treating human breast cancer with the antibodies or immunotoxins made therefrom are described.
机译:制备并表征了鼠单克隆抗体,其选择性结合人乳腺癌细胞,为IgG或IgM,并且与蓖麻蛋白A链结合后,对MCF-7,CAMA-1,SKBR-3中的至少一种表现出TCID 50%或小于约10 nM的BT-20细胞。描述了用由此产生的抗体或免疫毒素诊断,监测和治疗人乳腺癌的方法。

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