首页> 外国专利> A method for the production of 1 - chlorine - 2 - (1 - chlorine - cyclopropyl) - 3 - (2 - chlorine - phenyl) - propane - 2 - ol and / or 2 - (1 - chlorine - cyclopropyl) - 2 - (2 - chlorine - benzyl) - oxirane

A method for the production of 1 - chlorine - 2 - (1 - chlorine - cyclopropyl) - 3 - (2 - chlorine - phenyl) - propane - 2 - ol and / or 2 - (1 - chlorine - cyclopropyl) - 2 - (2 - chlorine - benzyl) - oxirane

机译：1-氯-2-（1-氯-环丙基）-3-（2-氯-苯基）-丙烷-2-ol和/或2-（1-氯-环丙基）2-的生产方法（2-氯-苄基）-环氧乙烷

页面导航

摘要
著录项
相似文献

摘要

A novel process can be used for the preparation of 1-chloro-2-(1-chloro-cyclopropyl)-3-(2-chlorophenyl)-propan-2-ol and/or 2-(1-chlorocyclopropyl)-2-(2-chloro-benzyl)-oxirane, by … … a) reacting 2-chloro-benzyl chloride with comminuted magnesium, optionally in the presence of a catalyst, in the presence of a mixture of toluene and tetrahydrofuran in which the toluene/tetrahydrofuran ratio is between 65:35 and 95:5 parts by weight, at temperatures between 0 DEG C and 100 DEG C, where the 2-chloro-benzyl chloride/ tetrahydrofuran ratio is such that between 1 and 3 moles of tetrahydrofuran are present per mole of 2-chloro-benzyl chloride, subsequently, if appropriate, removing any magnesium which may still be present, and … b) reacting the Grignard reagent formed with 1-chloro-1-chloroacetyl-cyclopropane in the presence of a mixture of toluene and tetrahydrofuran in which the toluene/tetrahydrofuran ratio is between 65:35 and 95:5 parts by weight, and, if appropriate, in the presence of an additional inert diluent, at temperatures between 0 DEG C and 100 DEG C. …

机译：一种新方法可用于制备1-氯-2-（1-氯-环丙基）-3-（2-氯苯基）-丙烷-2-醇和/或2-（1-氯环丙基）-2-醇（2-氯-苄基）-环氧乙烷，通过... a）使2-氯-苄基氯与粉碎的镁反应，任选在催化剂存在下，在甲苯和四氢呋喃的混合物存在下，其中甲苯/四氢呋喃在0℃至100℃的温度下，该比例为65∶35至95∶5重量份，其中2-氯苄基氯/四氢呋喃的比例使得每摩尔存在1-3摩尔之间的四氢呋喃。然后，在适当的情况下，除去2-氯苄基氯，除去可能仍然存在的任何镁，然后…b）在甲苯和乙腈的混合物存在下，使形成的格氏试剂与1-氯-1-氯乙酰基-环丙烷反应四氢呋喃，其中甲苯/四氢呋喃比为65:35至95：5重量份，并且在合适的情况下，在附加的惰性稀释剂，温度在0℃至100℃之间。…

著录项

公开/公告号DE4027608A1

专利类型
公开/公告日1992-03-05

原文格式PDF
申请/专利权人 BAYER AG 51373 LEVERKUSEN DE;
展开▼

申请/专利号DE19904027608
发明设计人 ROSEN WINFRIED DIPL.-CHEM. DR. 5600 WUPPERTAL DE;FIEDLER PAUL-CHRISTIAN DIPL.-CHEM. DR. 5000 KÖLN DE;BLUME GÖTZ DIPL.-CHEM. DR. 3450 HOLZMINDEN DE;
展开▼

申请日1990-08-31
分类号C07C25/18;C07D303/08;
国家 DE
入库时间 2022-08-22 05:25:52

相似文献

专利
外文文献
中文文献