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MONOCLONAL ANTIBODIES DIRECTED AGAINST ACTIVATED MICROGLIAL CELLS, HYBRIDOMAS SECRETING THESE MONOCLONAL ANTIBODIES, ANTIGEN RECOGNIZED BY THESE MONOCLONAL ANTIBODIES AND THEIR APPLICATIONS
MONOCLONAL ANTIBODIES DIRECTED AGAINST ACTIVATED MICROGLIAL CELLS, HYBRIDOMAS SECRETING THESE MONOCLONAL ANTIBODIES, ANTIGEN RECOGNIZED BY THESE MONOCLONAL ANTIBODIES AND THEIR APPLICATIONS
The invention relates to a monoclonal antibody which has the combination of the following properties: - it forms an immunological complex with a non-phosphorylated epitope of an antigen belonging to activated microglial cells of the central nervous system and released from a sonicated NFT preparation, itself isolated from the cerebral cortex obtained from a patient having Alzheimer's disease, - it forms an immunological complex with histiocytes and macrophages of the central nervous system, said monoclonal antibody can be used for the diagnosis in vitro of brain diseases involving activated microglial cells.
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