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Monoclonal antibody, process for preparing it, and diagnostic kit which is suitable for detecting and diagnosing human non-small cell lung cancer using the monoclonal antibody

机译:单克隆抗体,其制备方法和适用于使用该单克隆抗体检测和诊断人非小细胞肺癌的诊断试剂盒

摘要

Monoclonal antibodies 703D4 and 704A1 detect human non-small cell lung cancer (non-SCLC) and distinguish non-SCLC from all other types of lung cancer and normal tissue cells. These two antibodies may be utilized in kit form to distinguish non-SCLC from other forms of lung cancer. These monoclonal antibodies bind to S35 methionine-incorporating protein doublets under reduced and unreduced conditions. The determinants bound by these antibodies on the 31 kiladalton protein are independent of each other as determined in radiolabelled competition assays.
机译:单克隆抗体703D4和704A1检测人非小细胞肺癌(non-SCLC),并将非SCLC与所有其他类型的肺癌和正常组织细胞区分开。可以以试剂盒形式使用这两种抗体,以将非SCLC与其他形式的肺癌区分开。这些单克隆抗体在还原和未还原条件下均结合有S35蛋氨酸的蛋白质双峰。如在放射性标记的竞争测定中所确定的,在31 kiladalton蛋白上被这些抗体结合的决定簇彼此独立。

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