首页> 外国专利> covalently modified bacterial polysaccharidesstable covalent conjugates of polysaccharides and proteins with immunogenischen agents bridges and processes for the manufacture of such polysaccharides and conjugates and to befestiand the kovalenz.

covalently modified bacterial polysaccharidesstable covalent conjugates of polysaccharides and proteins with immunogenischen agents bridges and processes for the manufacture of such polysaccharides and conjugates and to befestiand the kovalenz.

机译：共价修饰的细菌多糖稳定的多糖和蛋白质与免疫原性试剂的共价结合物，以及制造此类多糖和结合物的方法，并以此命名科瓦伦茨。

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摘要

Covalently modified bacterial polysaccharides and proteins; covalent conjugates of such polysaccharides linked by a bigeneric spacer, which permits proof of covalency and facilitates purification of conjugated materials, with immunogenic bacterial membrane or other proteins, which conjugates are useful components of bacterial vaccines; and methods of preparing such polysaccharides, proteins and conjugates and of confirming the covalency of the linkage between polysaccharides and proteins.

机译：共价修饰的细菌多糖和蛋白质;通过双能间隔物连接的这种多糖的共价结合物，其可以证明共价性，并有助于与免疫原性细菌膜或其他蛋白质的结合物的纯化，这些结合物是细菌疫苗的有用成分;以及制备此类多糖，蛋白质和缀合物的方法，以及确定多糖与蛋白质之间的键的共价性的方法。

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公开/公告号DE3582356D1

专利类型
公开/公告日1991-05-08

原文格式PDF
申请/专利权人 MERCK & CO. INC. RAHWAY N.J. US;
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申请/专利号DE19853582356T
发明设计人 MARBURG STEPHEN METUCHEN NEW JERSEY 08840 US;KNISKERN PETER J. LANSDALE PENNSYLVANIA 19446 US;TOLMAN RICHARD L. WARREN NEW JERSEY 07060 US;
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申请日1985-05-06
分类号C07K17/06;C07K17/10;A61K39/385;A61K39/39;G01N33/50;
国家 DE
入库时间 2022-08-22 05:50:05

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