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TRANSGENIC TESTING SYSTEMS FOR MUTAGENS AND CARCINOGENS

机译:突变和致癌物转基因检测系统

摘要

Non-human transgenic animal testing systems for mutagens and carcinogens are described. Recombinant DNA techniques are used to create unique test genes and regulation signals for detecting increased frequencies of mutations produced by mutagens and cancers induced by carcinogens. The test genes are introduced into the germ line of non-human transgenic animals to provide a unique bioassay panel for mutagens and carcinogens. The test genes of the invention may encode any of a number of different genes, the expression of which could be detected in a transgenic animal. However, the test gene is engineered so that the expression of the test gene product is either prevented or inhibited unless the gene is activated by a mutagen or carcinogen.
机译:描述了用于诱变剂和致癌物的非人类转基因动物测试系统。重组DNA技术用于创建独特的测试基因和调控信号,以检测诱变剂和致癌物诱发的癌症产生的突变频率增加。将测试基因引入非人类转基因动物的种系中,为诱变剂和致癌物提供独特的生物测定方法。本发明的测试基因可以编码许多不同的基因中的任何一种,可以在转基因动物中检测到其表达。但是,对测试基因进行工程改造,以便除非该基因被诱变剂或致癌物激活,否则将阻止或抑制该测试基因产物的表达。

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