首页> 外国专利> MONOCLONAL ANTIBODIES DIRECTED AGAINST PROTEINS INVOLVED IN PLAQUETTARY FUNCTIONS, THEIR APPLICATIONS AS DIAGNOSTIC AND THERAPEUTIC AGENTS

MONOCLONAL ANTIBODIES DIRECTED AGAINST PROTEINS INVOLVED IN PLAQUETTARY FUNCTIONS, THEIR APPLICATIONS AS DIAGNOSTIC AND THERAPEUTIC AGENTS

机译:涉及单克隆蛋白的单克隆抗体针对斑块功能的定向表达及其在诊断和治疗中的应用

摘要

The invention concerns monoclonal antibodies or idiotypic fragments of these monoclonal antibodies, recognizing antigens involved in the stages of plaquettary physiology and in particular, in adhesion and/or aggregation reactions and/or plaquettary secretion, and/or adhesion of endothelial cellules characterized by having the capacity to modulate the plaquettary functions or the endothilial functions induced by a small concentration of aganists, for example in the presence of 2.5 to 5νM of ADP, 2 νg/ml of collagen, 0.016 U/ml of thrombine, and by the fact that their ability to inhibit the plaquettary functions is considerably reduced, even non-existent, in the presence of high concentrations of aganists, for example in the presence of concentrations of thrombine above 0.5 U/ml or of collagen above 10νg/ml. The invention also concerns the diagnostic and therapeutic application of these antibodies.
机译:本发明涉及单克隆抗体或这些单克隆抗体的独特型片段,其识别与斑块生理阶段有关的抗原,特别是与粘附和/或聚集反应和/或斑块分泌和/或内皮细胞粘附有关的抗原,其特征在于具有能够调节少量浓缩剂诱导的induced功能或内皮功能,例如在2.5至5νM的ADP,2νg/ ml的胶原蛋白,0.016 U / ml的血栓素的存在下,在存在高浓度的促排剂的情况下,例如在浓度高于0.5 U / ml的苏氨酸或浓度高于10vg / ml的胶原蛋白的情况下,抑制纤毛功能的能力大大降低,甚至根本不存在。本发明还涉及这些抗体的诊断和治疗应用。

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