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TISSUE SPECIFIC VIRAL VECTORS BASED ON LYMPOTROPIC PAPOVAVIRUS LPV

机译：基于溶血性PAPOVAVIRUS LPV的组织特定病毒载体

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摘要

Vectors which contain the origin of DNA replication and essentially the late gene region of lymphotropic papova virus (LPV) are suitable for the transfecton of LPV-permissive cells which stably express the early gene region of LPV. Foreign DNA incorporated into the vectors is then replicated in these cells and packaged into LPV particles. It is possible by utilising the host specificity of LPV for B-lymphoma cells to introduce the foreign DNA into cells by infection with these replication-defective particles and to express it therein. When the foreign DNA codes for a protein which is toxic for the infected cells, this vector system can be used for the therapy of B lymphomas.

机译：包含DNA复制起点和基本上是淋巴细胞性巴氏病毒（LPV）晚期基因区域的载体适用于LPV允许细胞的转染子，该细胞稳定表达LPV的早期基因区域。掺入载体的外源DNA然后在这些细胞中复制并包装成LPV颗粒。通过利用LPV对B淋巴瘤细胞的宿主特异性，可以通过感染这些复制缺陷颗粒而将外源DNA导入细胞中并在其中表达。当外源DNA编码对被感染细胞有毒的蛋白质时，该载体系统可用于治疗B淋巴瘤。

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公开/公告号AU604753B2

专利类型
公开/公告日1991-01-03

原文格式PDF
申请/专利权人 BEHRINGWERKE AKTIENGESELLSCHAFT;
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申请/专利号AU19870078670
发明设计人 HARALD ZUR HAUSEN;MICHAEL PAWLITA;
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申请日1987-09-18
分类号C12P21/00;A61K31/70;A61K39/12;C07G17/00;C12N5/00;C12N5/10;C12N7/00;C12N15/00;C12N15/86;C12P19/34;
国家 AU
入库时间 2022-08-22 05:55:17

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