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MONOCLONAL ANTIBODIES FOR NON-SMALL CELL LUNG CARCINOMAS(NSCLC)AND DIAGNOSTIC METHOD AND KIT FOR DETECTING MALIGNANT CELLS ASSOCIATED WITH NSCLC USING SUCH ANTIBODIES
MONOCLONAL ANTIBODIES FOR NON-SMALL CELL LUNG CARCINOMAS(NSCLC)AND DIAGNOSTIC METHOD AND KIT FOR DETECTING MALIGNANT CELLS ASSOCIATED WITH NSCLC USING SUCH ANTIBODIES
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机译:非小细胞肺癌的单克隆抗体及其诊断方法和试剂盒用这种抗体检测与NSCLC相关的恶性细胞
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摘要
The present invention is concerned with two novel monoclonal antibodies which define carbohydrate antigens associated with human non-small cell lung carcinomas ("NSCLC") and certain other human carcinomas. The antibodies bind to normal human cells to a much lesser degree than to tumor cells. The antibodies find use in diagnostic methods such as the detection of malignant cells associated with NSCLC and in therapeutic methods. The invention also comprises a method for determining the presence of a malignant condition in the lung of a subject. The method involves examining tissue from the subject for the presence of antigens which are Lex or Ley antigen or which have the characteristics of Ley and Lex.
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