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REMEDY COMPOSITION FOR ANTI-HYPERTENSION AND ANTI-CONGESTIVE HEART FAILURE
REMEDY COMPOSITION FOR ANTI-HYPERTENSION AND ANTI-CONGESTIVE HEART FAILURE
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机译：抗高血压和抗充血性心力衰竭的药物组成
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摘要
PURPOSE: To obtain a medicine composition useful for hypertension, comprising a potassium channel activator and an inhibitor of angiotensin converting enzyme. CONSTITUTION: This composition comprises (A) a compound of the formula [V is a CR1 (R1 is H, a halogen, thienyl, etc.); T is a CR2 (R2 is H, a halogen, a 1-4C alkoxy, hydroxy, etc.); W is HC or V is N, T is a CR2 and W is CH; or V and W are each N and T is CH, etc.; R3 and R4 are each H, a 1-4C alkyl or bonded to form (CH2 )n ((n) is 2-5); R5 is H or OR8 (R8 is H, a 1-4C alkyl, formyl, etc.); R9 and R10 are each H, methyl or bonded to form oxo or thio; (m) is 1-3; X is NR11 (R11 is H, an alkyl, acetyl, etc.); Y is CH, a C-halogen, N, etc.; Z is CH2 O, S, etc.], its N-oxide, its acid addition salt or quaternary ammonium salt and (B) an inhibitor of angiotensin converting enzyme in the weight ratio of the components A:B of 1:5 to 1:20, preferably 1:10 to 1:15.
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