首页> 外国专利> ENZYME BIOSENSOR FOR DIRECT MEASUREMENT OF AT LEAST ONE BIOCHEMICAL PARAMETER OF THE SKIN, PROCESS FOR PREPARING THE ENZYMATIC MEMBRANE THEREOF AND MEASURING METHOD THEREFOR

ENZYME BIOSENSOR FOR DIRECT MEASUREMENT OF AT LEAST ONE BIOCHEMICAL PARAMETER OF THE SKIN, PROCESS FOR PREPARING THE ENZYMATIC MEMBRANE THEREOF AND MEASURING METHOD THEREFOR

机译：直接测量皮肤至少一个生物化学参数的酶生物传感器，制备其酶膜的方法及其测量方法

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摘要

This biosensor comprises a membrane 8 in which is immobilized an enzyme catalyzing the transformation of a substrate involved in the skin metabolism, means for detecting and measuring a phenomenon caused by this transformation, representative of the concentration of the substrate to be assayed brought into contact with the membrane 8 and a measurement cell 13, a wall area of which is formed by the membrane 8, and which is capable of being closed, during the measurement, by a skin covering area 15, the cell 13 being associated with means for circulating therein a liquid for dissolving the substrate to be dosed. For the measurement, the biosensor is applied to the skin, buffer is injected into the cell and once the latter is filled, detection and measurement are carried out, then buffer is again circulated to remove the solubilized substrate. This measurement cycle can be repeated without removing electrode 1. Application to the determination of cutaneous L-lactate by a Clark electrode associated with an L-lactate oxidase membrane.

机译：该生物传感器包括膜8，在膜8中固定有催化参与皮肤代谢的底物转化的酶，用于检测和测量由这种转化引起的现象的装置，该现象代表与之接触的待分析底物的浓度。膜8和测量室13，其壁区域由膜8形成，并且能够在测量过程中通过皮肤覆盖区域15封闭，测量室13与在其中循环的装置相关联用于溶解待计量基质的液体。为了进行测量，将生物传感器应用于皮肤，将缓冲液注入细胞中，一旦细胞充满，进行检测和测量，然后再次循环缓冲液以去除溶解的底物。可以在不去除电极1的情况下重复此测量周期。用于与L-乳酸盐氧化酶膜相关的Clark电极测定皮肤L-乳酸盐。

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公开/公告号FR2640643A1

专利类型
公开/公告日1990-06-22

原文格式PDF
申请/专利权人 OREAL;OREAL;
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申请/专利号FR19880016664
发明设计人 BERNARD DOMINIQUE;DOMINIQUE BERNARD;KERMICI MICHEL;MICHEL KERMICI;PRUNIERAS MICHEL;MICHEL PRUNIERAS;
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申请日1988-12-16
分类号G01N27/327;A61B5/00;A61B5/103;A61B10/00;C12Q1/00;
国家 FR
入库时间 2022-08-22 06:09:17

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