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Treating auto-immune disease with platelet activating factor - opt. formulated with immunosuppressant, esp. for idiopathic thrombocytopaenic purpura

机译：用血小板活化因子治疗自身免疫性疾病-opt。配制有免疫抑制剂，特别是用于特发性血小板减少性紫癜

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The use of PAF (platelet activating factor) antagonists (I) for treatment of autoimmune diseases, specifically idiopathic thrombocytopaenic purpura (ITP) is new. (I) is pref. a thieno(3,2-f) (1,2,4)-triazolo (4,3-a) (1,4) diazepine or (1,2,4) triazolo (4,3-a) (1,4) benzodiazepine deriv. and (II) is cyclosporin. (I) is 6-(2-chlorophenyl)-8,9-dihydro-1 -methyl-8-R-4H,7H cyclopenta (4,5) thieno (3,2-f) (1,2,4) triasolo (4,3-a) (1,4) diazepine (R = 4-morpholinylcarbonyl or dipropylaminocarbonyl) or 4-(2-chlorophenyl)-9- methyl -2-(3-(4-morpholinyl)-3-propanon-1-yl)-6H- thieno (3,2-f) (1,2,4) triazolo (4,3-a) (1,4) diazepine (Ia). USE/ADVANTAGE - (I) are effective against ITP, causing a rapid increase in the thrombocyte count, without the side effects associated with steroid therapy. Usual doses are 5-50 mg orally or 2.5-30 mg intravenously. When formulated with (II), (I) allows the dose (and thus the side effects) of (II) to be reduced.

机译：PAF（血小板活化因子）拮抗剂（I）用于治疗自身免疫性疾病，特别是特发性血小板减少性紫癜（ITP）的用途是新的。（I）是首选。 Thieno（3,2-f）（1,2,4）-triazolo（4,3-a）（1,4）diazepine或（1,2,4）triazolo（4,3-a）（1， 4）苯二氮卓衍生物。（II）是环孢菌素。（I）是6-（2-氯苯基）-8,9-二氢-1-甲基-8-R-4H，7H环戊（4,5）噻诺（3,2-f）（1,2,4）三唑（4,3-a）（1,4）二氮杂（R = 4-吗啉基羰基或二丙基氨基羰基）或4-（2-氯苯基）-9-甲基-2-（3-（4-吗啉基）-3-丙烷-1-基）-6H-噻吩并（3,2-f）（1,2,4）三唑（4,3-a）（1,4）二氮杂（Ia）。使用/优点-（I）对ITP有效，可引起血小板计数快速增加，而没有类固醇疗法的副作用。通常的剂量是口服5-50mg或静脉内2.5-30mg。当与（II）一起配制时，（I）允许减少（II）的剂量（因此副作用）。

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公开/公告号DE3927804A1

专利类型
公开/公告日1990-03-01

原文格式PDF
申请/专利权人 BOEHRINGER INGELHEIM KG 6507 INGELHEIM DE;
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申请/专利号DE19893927804
发明设计人 LOHMANN HELMUT DR. 6507 INGELHEIM DE;FROELKE WILHELM DIPL.-CHEM. DR. 6507 INGELHEIM DE;MEADE CHRISTOPHER JOHN MONTAGUE DR. 6530 BINGEN DE;
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申请日1989-08-23
分类号A61K31/55;A61K37/02;
国家 DE
入库时间 2022-08-22 06:10:06

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