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Process for the preparation of recombinant vectors and Recombinant HBsAg particles having the characteristics of hybrid morfologicas antigenio HBsAg containing a sequence that induces immunologicNeutralising antibodies directed against HIV or liable to be recognized by such antibodies.
Process for the preparation of recombinant vectors and Recombinant HBsAg particles having the characteristics of hybrid morfologicas antigenio HBsAg containing a sequence that induces immunologicNeutralising antibodies directed against HIV or liable to be recognized by such antibodies.
The invention relates to an active principle of the vaccine against hiv. This active principle consists of particles that have the essential morphological characteristics of the particles of hbsag, and comprising, flush with the surface of these particles, the essential part of the amino acid sequence is coded by the area s and, if appropriate, all or part of the amino acid sequence encoded by the pre - s of the genome of the hepatitis b virus, upstream of the amino acid sequence s, these recombinant particles being characterized in that they comprise, in addition, an amino acid sequence immunogenic inducing antibodies screw - to - a family of the hiv retrovirus or capable of being recognized by antibodies, this sequence comprising it - even at least an epitope which is capable of being recognized by the b lymphocytes, and at least an epitope which is capable of being recognized by the t lymphocytes and, if necessary, at least one site for attachment to the receiver, cd4 lymphocytes t4 humans, the immunogenic sequence, is inserted in the sequence of amino acids pre - s, or substituted all or part of the protein pre - s.
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