首页>
外国专利>
PROCESS FOR THE PREPARATION OF COMPOUNDS TRANS-6- {2- (3- (4-CARBOXANIDE-PYRROLE-SUBSTITUTED-1-YL) ALKYL) -4-HYDROXYPYRAN-2-ONA INHIBITORS OF SYNTHESIS OF CHOLESTEROL AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
PROCESS FOR THE PREPARATION OF COMPOUNDS TRANS-6- {2- (3- (4-CARBOXANIDE-PYRROLE-SUBSTITUTED-1-YL) ALKYL) -4-HYDROXYPYRAN-2-ONA INHIBITORS OF SYNTHESIS OF CHOLESTEROL AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
Certain trans-6-[2-(3- or 4-carboxamido-substitutedpyrrol-1-yl)alkyl]-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reductase) and are thus useful hypolipidemic or hypocholesterolemic agents. Pharmaceutical compositions containing such compounds, and a method of inhibiting the biosynthesis of cholesterol employing such pharmaceutical compositions are also disclosed.
展开▼
