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Benzenjudotai

机译:苯爵皮带

摘要

NEW MATERIAL:A (4-benzyloxy)phenyl(5-halogenopentyl) ether shown by formula I (X is halogen). EXAMPLE:[4-Benzyloxy]phenyl[5-bromopentyl] ether. USE:Useful as a raw material for producing omega-(1-imidazolyl)pentyloxybenzene derivative having lipid lowering action, especially excellently lowering action on cholesterol and triglyceride and further inhibitory action on aggregation of blood platelet and useful for treating and remedying arteriosclerosis, cerebral infarct, transient ischemic attack or angina pectoris. PREPARATION:For example, as shown by the reaction formula, sodium phenoxide shown by formula II is reacted with a 1,5-dihalogenopentyl shown by formula III in a mixed solution of benzene-dimethylformamide to give a compound shown by formula I.
机译:新材料:式I所示的(4-苄氧基)苯基(5-卤代戊基)醚(X为卤素)。实施例:[4-苄氧基]苯基[5-溴戊基]醚。用途:用作生产具有降脂作用,特别是对胆固醇和甘油三酸酯有极好的降低作用,并进一步抑制血小板聚集的作用的ω-(1-咪唑基)戊氧基苯衍生物的原料,可用于治疗和治疗动脉硬化,脑梗死,短暂性脑缺血发作或心绞痛。制备:例如,如反应式所示,使式II所示的苯酚钠与式III所示的1,5-二卤代戊基在苯-二甲基甲酰胺的混合溶液中反应,得到式I所示的化合物。

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