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PROCESS FOR PRODUCING INDOLOQUINOXALINE DERIVATIVES WITH SUBSTITUENT IN 6-POSITION CONTAINING CYCLIC GROUP, AS WELL AS PHARMACEUTICALS COMPRISING THESE COMPOUNDS AS ACTIVE INGREDIENT
PROCESS FOR PRODUCING INDOLOQUINOXALINE DERIVATIVES WITH SUBSTITUENT IN 6-POSITION CONTAINING CYCLIC GROUP, AS WELL AS PHARMACEUTICALS COMPRISING THESE COMPOUNDS AS ACTIVE INGREDIENT
Novel indoloquinoxalines having substituents in 6-position containing cyclic groups, of the general formula I …CHEM… wherein R1 represents hydrogen or one or several preferably 1 to 4, similar or different substituents in the positions 1-4 and/or 7-10, selected from halogen, lower alkyl-/alkoxy group having not more than 4 carbon atoms, trifluoromethyl group, trichloromethyl group;… X is a group …CHEM… wherein Y is CH2, NH, O or S and a is 2, 3 or 4 and wherein also the bond -C=N- can be saturated; Z is alkyl having 1-6 carbon atoms, Cl, Br or CF3 and… R3 represents hydrogen, lower alkyl-/cykloalkyl group having not more than 4 carbon atoms,… and the physiologically acceptable addition products of the compounds with acids and halogen adducts are described. Also methods for preparing said compounds by reaction of a compound of the formula II …CHEM… with a reactive compound containing the residue -CHR3X or by rearranging a compound of the formula III …CHEM… by heating, are described. …??The novel indoloquinoxalines have antiviral effect and have effect against cancer.
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