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PREPARATION OF ANTIBIOTIC SUBSTANCE AT-265 AND/OR AT-265-B

机译:AT-265和/或AT-265-B的抗菌物质的制备

摘要

PURPOSE:To accumulate and collect the titled antibiotics having the antimicrobial activity against Gram-positive and Gram-negative bacteria, by cultivating a microorganism belonging to the genus Streptomyces. CONSTITUTION:A microorganism, e.g. Streptomyces rishiriensis subspecies SP- 265, is cultivated in a usual culture medium for cultivating actinomyces, e.g. containing glucose, starch, meat extract, corn steep liquor, phosphate or carbonate. Microbial cells are removed from the culture by the filtration, etc. and the aimed novel antibiotic substance AT-265 or AT-265-B or both are obtained from the filtrate by the adsorption and desorption method with an ion exchange resin, silica gel chromatography, etc.
机译:目的:通过培养属于链霉菌属的微生物来积累和收集对革兰氏阳性和革兰氏阴性细菌具有抗菌活性的标题抗生素。组成:一种微生物,例如在常规培养基中培养利什氏链霉菌(Streptomyces rishiriensis)亚种SP-265,以用于培养放线菌,例如大肠杆菌。包含葡萄糖,淀粉,肉提取物,玉米浆,磷酸盐或碳酸盐。通过过滤等将微生物细胞从培养物中除去,将目标的新型抗生素物质AT-265或AT-265-B或两者通过利用离子交换树脂,硅胶色谱的吸附解吸法从滤液中获得。等

著录项

  • 公开/公告号JPH0123117B2

    专利类型

  • 公开/公告日1989-05-01

    原文格式PDF

  • 申请/专利权人 BETSUPU TERUHIKO;

    申请/专利号JP19810053879

  • 发明设计人 BETSUPU TERUHIKO;

    申请日1981-04-10

  • 分类号C12P19/40;C07H19/167;C12R1/465;

  • 国家 JP

  • 入库时间 2022-08-22 06:44:06

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