Cefazolin is prepared by treating a solvate of N,N- dimethylformamide and the hydrochloride salt of 7-amino-3-(2-methyl-1,3,4- thiadiazol-5-yl) thiomethyl-3-cephem-4-carboxylic acid with 1H-tetrazole- 1-acetyl chloride in the presence of N,N-dimethylacetamide as solvent.
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