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Methods of treating depression and depressive states using 5- phenyl-1,4,5, 6-tetrahydropyrimidine derivatives

机译：使用5-苯基-1,4,5,6-四氢嘧啶衍生物治疗抑郁和抑郁状态的方法

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摘要

The present invention relates to new derivatives selected from the group comprising:PP(i) the 5-phenylhydropyrimidines of the formula: ##STR1## in which: X.sub.1 and X.sub.2, which are identical or different, each represent H, F, Cl, Br or CF.sub.3, and P PA represents a polyhydropyrimidinyl group of the structure: ##STR2## in which: Y represents H or OH,PPR. sub.a represents a C. sub.1 -C.sub.4 alkyl group or a C.sub.2 -C.sub.5 alkanoyl group, it being possible for R.sub.a to represent the hydrogen atom when at least one of the groups X.sub.1, X.sub.2 and Y is different from H,PPR. sub.b represents a C.sub.1 -C.sub.3 alkyl group, andPPR. sub.c.sup.1 and R.sub.c.sup.2, which are identical or different, each represent the hydrogen atom or a C.sub.1 -C. sub.3 alkyl group; and PP(ii) their addition salts. PPThe said derivatives are useful as pharmaceuticals.

机译：本发明涉及选自以下的新衍生物：（P）式（I）的5-苯基氢嘧啶，其中：X.sub.1和X.sub.2，相同或不同的基团，分别代表H，F，Cl，Br或CF 3，且

A代表结构为：## STR2 ##的多氢嘧啶基，其中：Y代表H或OH，P R。亚基表示C 1 -C 4烷基或C 2 -C 5烷酰基，R a代表氢原子时， X，X2和Y基团中的至少一个与H，P R不同。 b代表C 1 -C 3烷基，和

R。相同或不同的subsc.1和RCsubs.2，分别代表氢原子或C1-C。 sub.3烷基; （ii）它们的加成盐。所述衍生物可用作药物。展开▼

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公开/公告号US4774248A

专利类型
公开/公告日1988-09-27

原文格式PDF
申请/专利权人 SOCIETE ANONYME DITE: LABORATOIRE L. LAFON;
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申请/专利号US19860941158
发明设计人 LOUIS LAFON;
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申请日1986-12-12
分类号A61K31/505;C07D239/06;
国家 US
入库时间 2022-08-22 06:48:34

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