首页> 外国专利> Inhibitor of the activity of plasma C1-esterase (C1-inhibitor) and of other proteolytic enzymes of the serine protease group, process for preparing it, nucleic acids encoding this inhibitor, methods for detecting diseases linked to deficiencies in the said inhibitor using antibodies or nucleotide probes and medicinal products containing the said synthetic inhibitor

Inhibitor of the activity of plasma C1-esterase (C1-inhibitor) and of other proteolytic enzymes of the serine protease group, process for preparing it, nucleic acids encoding this inhibitor, methods for detecting diseases linked to deficiencies in the said inhibitor using antibodies or nucleotide probes and medicinal products containing the said synthetic inhibitor

机译：血浆C1酯酶（C1抑制剂）和丝氨酸蛋白酶基团其他蛋白水解酶活性的抑制剂，其制备方法，编码该抑制剂的核酸，使用抗体或抗体检测与所述抑制剂缺陷相关的疾病的方法含有所述合成抑制剂的核苷酸探针和药物

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摘要

C1-INH inhibitor, or fragments thereof, prepared using a process for the construction of bacterial or recombinant clones, or of recombinant eucaryotic cells containing a cDNA which encodes human C1-INH. Process for the construction of the said clones or cells. Application especially to the detection and to the treatment of diseases linked to deficiencies in the said inhibitor and in particular of hereditary angioneurotic oedema. IMAGE

机译：使用构建细菌或重组克隆或含有编码人C1-INH的cDNA的重组真核细胞的方法制备的C1-INH抑制剂或其片段。所述克隆或细胞的构建方法。特别是用于检测和治疗与所述抑制剂缺陷有关的疾病，特别是遗传性血管神经性水肿的应用。 <图像>

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公开/公告号FR2601034A1

专利类型
公开/公告日1988-01-08

原文格式PDF
申请/专利权人 PASTEUR INSTITUT;INSTITUT NAL SANTE RECHERC MEDIC;
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申请/专利号FR19860009662
发明设计人 MARIO TOSI CHRISTIANE DUPONCHEL ET TOMMASO MEO;DUPONCHEL CHRISTIANE;MEO TOMMASO;
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申请日1986-07-03
分类号C12N15/00;A61K37/64;C07H21/04;C07K13/00;C12P19/34;C12P21/02;
国家 FR
入库时间 2022-08-22 06:51:07

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