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TRANSDERMAL DELIVERY SYSTEM FOR THE ADMINISTRATION OF FENTANYL.
TRANSDERMAL DELIVERY SYSTEM FOR THE ADMINISTRATION OF FENTANYL.
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机译:芬太尼经皮给药系统。
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摘要
Transdermal delivery systems for delivery of fentanyl and its analgetically effective derivatives for extended periods of time are disclosed which deliver the base form of the drug at a rate of from 0.5 to 10 mu g/cm2/hr for a substantial portion of their useful life. The systems can be from 5-100 cm2 in releasing surface and preferably employ an in-line amine resistant adhesive. Preferred rate controlled systems utilize an aqueous ethanolic gel to minimize drug content.
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机译:公开了用于长时间递送芬太尼及其镇痛有效衍生物的透皮递送系统,其在相当长的使用寿命中以0.5至10μg/ cm 2 / hr的速率递送药物的基本形式。该体系的释放表面可以为5-100cm 2,并且优选采用在线抗胺粘合剂。优选的速率控制系统利用含水乙醇凝胶以最小化药物含量。
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