首页> 外国专利> 1*44BENZODIAZEPIN DERIVATIVES*THEIR MANUFACTURE AND MEDICAL DRUG ACTIVE TO CENTER CONTROL*ANTISPASM*MUSCLE RELAXATION*ANXIETY MOLLIFICATION AND TRANQUILIZATION

144BENZODIAZEPIN DERIVATIVESTHEIR MANUFACTURE AND MEDICAL DRUG ACTIVE TO CENTER CONTROLANTISPASMMUSCLE RELAXATION*ANXIETY MOLLIFICATION AND TRANQUILIZATION

机译：1 * 44苯并二氮杂卓衍生物*它们的制造和药用药物对中心控制有效*抗寄生虫药*肌肉松弛*焦虑症的转移和转化

页面导航

摘要
著录项
相似文献

摘要

New 1,4-benzodiazepine derivatives are disclosed which are substituted in 2-position by cyanomethylene or carbamoylmethylene and have the formula IMAGE wherein R1 represents hydrogen, halogen, or nitro, R2 represents hydrogen or lower alkyl, R3 represents phenyl which may be substituted by halogen or CF3, and R4 represents cyano or carbamoyl. The compounds exhibit tranquilizing activities. The cyanomethylene-compounds are prepared by oxidizing corresponding cyanomethyl compounds with Cr-VI-oxide in an acidic reaction medium. The cyanomethylene-group can subsequently be hydrolyzed into the carbamoylmethylene group.

机译：公开了新的1，4-苯并二氮杂卓衍生物，其在2-位被氰基亚甲基或氨基甲酰基亚甲基取代并且具有式，其中R 1代表氢，卤素或硝基，R 2代表氢或低级烷基，R 3代表苯基，可以是被卤素或CF3取代，并且R4代表氰基或氨基甲酰基。这些化合物表现出镇定活性。通过在酸性反应介质中用Cr-VI-氧化物氧化相应的氰基甲基化合物来制备氰基亚甲基化合物。随后可以将氰基亚甲基水解为氨基甲酰基亚甲基。

著录项

公开/公告号JPS6310698B2

专利类型
公开/公告日1988-03-08

原文格式PDF
申请/专利权人 KALI CHEMIE PHARMA GMBH;
展开▼

申请/专利号JP19780147316
发明设计人 HANSU RIIPUMAN;RORUFU HYUSHENSU;UORUFUGANGU MIRUKOFUSUKII;HORUSUTO TSUOIGUNERU;RENKE BUTSUDEN;JAKURIIN BAARUZEN;
展开▼

申请日1978-11-30
分类号A61K31/55;A61K31/551;A61P21/02;A61P25/00;A61P25/08;A61P25/20;A61P25/26;C07D243/16;
国家 JP
入库时间 2022-08-22 07:07:45

相似文献

专利
外文文献
中文文献