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首页> 外国专利> INFLUENZA VACCINE COMPRISING A HEMAGGLUTININ-NEURAMINIDASE (HANA) ANTIGEN AND A MURAMYLDIPEPTIDE (MDP) ADJUVANT

INFLUENZA VACCINE COMPRISING A HEMAGGLUTININ-NEURAMINIDASE (HANA) ANTIGEN AND A MURAMYLDIPEPTIDE (MDP) ADJUVANT

机译：包含血凝素神经氨酸酶（HANA）抗原和甲基二肽（MDP）辅助剂的流感疫苗

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摘要

This invention relates to a novel influenza vaccine comprising a complex of HANA antigen and an MDP derivative. The novel vaccine is prepared by mixing an influenza HANA antigen and at least one MDP derivative in a suitable medium; solubilizing the resulting mixture with a surface active agent capable of being removed by dialysis, the solubilization being conducted in the presence or absence of cholesterol, lecithin and dicetyl phosphate or a mixture thereof; and then removing the surface active agent therefrom by dialysis to obtain an influenza vaccine comprising artificial vesicle-like particles of a complex of HANA antigen and MDP derivative, where the MDP derivative forms a membrane of the particle (corresponding to the lipid membrane of natural influenza virus particle) on the surface of which there exists the HANA antigen being bonded to the MDP derivative so as to form the complex. Thus, said artificial vesicle-like particle of the HANA antigen-MDP derivative complex has nearly the same particle size and shape as the natural influenza virus particle. The novel vaccine has an improved immunogenicity compared with the conventional vaccine.
机译：本发明涉及一种新型流感疫苗，其包含HANA抗原和MDP衍生物的复合物。通过在合适的培养基中混合流感HANA抗原和至少一种MDP衍生物来制备新型疫苗。用能够通过透析除去的表面活性剂增溶所得混合物，增溶在存在或不存在胆固醇，卵磷脂和磷酸二鲸蜡酯或其混合物的情况下进行。然后通过透析从中去除表面活性剂以获得包含HANA抗原和MDP衍生物的复合物的人工囊状颗粒的流感疫苗，其中MDP衍生物形成颗粒的膜（对应于天然流感的脂质膜病毒颗粒），在其表面上存在与MDP衍生物结合形成复合物的HANA抗原。因此，所述HANA抗原-MDP衍生物复合物的人工小泡样颗粒具有与天然流感病毒颗粒几乎相同的粒径和形状。与常规疫苗相比，该新型疫苗具有改善的免疫原性。

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