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A procedure for the preparation diazohidroxidos pyrazine.

机译:重氮重氮吡嗪的制备方法。

摘要

Procedure for obtaining diazohidroxidos pyrazine, of formula (i).Involves the reaction of a aminopirazina diazotacion Derivative of formula (ii) for Treatment with an alkyl NITRITE, such as isoanilo NITRITE in the presence of a base between alkali metal hydroxides, amides and organometallic compounds in tetrahydrofuran as solvent. To obtain the compound of formula (i),In which M is an Alkaline Earth Metal or equivalent and R may be one of several radical; and separation of the compound formed by Ion Exchange Chromatography. These compounds have pharmacological applications as cytostatic agents and Agents that inhibit cell growth.
机译:制备式(i)的重氮吡唑并吡嗪的方法。涉及在碱金属氢氧化物,酰胺和有机金属之间存在碱的情况下,用式(ii)的氨基吡唑啉氮重氮酮衍生物进行反应,以烷基NITRITE(例如异苯胺NITRITE)处理化合物以四氢呋喃为溶剂。为了获得式(i)的化合物,其中M是碱土金属或等同物,R可以是多个基团之一;并通过离子交换色谱分离形成的化合物。这些化合物作为细胞抑制剂和抑制细胞生长的药物具有药理学应用。

著录项

  • 公开/公告号ES8702373A1

    专利类型

  • 公开/公告日1987-03-16

    原文格式PDF

  • 申请/专利权人 BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA;

    申请/专利号ES19850548790

  • 发明设计人

    申请日1985-11-12

  • 分类号C07D241/06;

  • 国家 ES

  • 入库时间 2022-08-22 07:17:14

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