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A procedure for the preparation diazohidroxidos pyrazine.
A procedure for the preparation diazohidroxidos pyrazine.
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机译:重氮重氮吡嗪的制备方法。
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摘要
Procedure for obtaining diazohidroxidos pyrazine, of formula (i).Involves the reaction of a aminopirazina diazotacion Derivative of formula (ii) for Treatment with an alkyl NITRITE, such as isoanilo NITRITE in the presence of a base between alkali metal hydroxides, amides and organometallic compounds in tetrahydrofuran as solvent. To obtain the compound of formula (i),In which M is an Alkaline Earth Metal or equivalent and R may be one of several radical; and separation of the compound formed by Ion Exchange Chromatography. These compounds have pharmacological applications as cytostatic agents and Agents that inhibit cell growth.
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