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labdano derivatives, process for their preparation, and pharmaceutical compositions containing derivatives of labdano
labdano derivatives, process for their preparation, and pharmaceutical compositions containing derivatives of labdano
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机译：拉达诺衍生物，其制备方法以及含有拉达诺衍生物的药物组合物
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摘要
This invention relates to a pharmaceutical composition eliciting an antiallergic and/or bronchodilatory effect, which comprises a compound of general formula I …CHEM… including the 5,6 and 6,7 dehydro derivatives, in the free form or in the form of its solvate,… wherein U is O or (H,R1);… V is O or (H,R2);… wherein R1 is H or OR11, wherein R11 is H or acyl, R2 is H, OR11, OSO2R min or OR min , wherein R min is alkyl; or when R1 and R2 are taken together they may form …CHEM… R3 is hydrogen, alkyl, CH2OH, CHO, CO2R15, -CH=CR16R17, -C IDENTICAL C-R18, -CHOH-C IDENTICAL C-R19;… -CH=C=CHR19, -CH=H-OR19, …CHEM… wherein Z is O or S, …CHEM… -CN=N-NDE or… -CH(ZR20)2 wherein Z is defined as above;… R4 is H or OH;… R5 is OH; or when… R4 and R5 are taken together they may form …CHEM… wherein Z is defined as above;… X is O or H/OR sec wherein R sec is H, carboxylic acyl or trifluoroacetyl;… Q is hydrogen, chlorine or bromine; or Q together with R3 may form a bond between the carbon atoms of positions 12 and 13; whereby in the 5,6-dehydro-derivatives of formula I R1 is H and in the 6,7-dehydro-derivatives of formula I R1 and R2 are H;… and wherein R11, R13, R14, T15, R16, R17, R18, R19, R20, A, B, D, and E are as defined in the claims. …??Part of the compounds of formula I are new compounds.
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