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A HUMAN PHYSIOLOGICALLY ACTIVE POLYPEPTIDE DEOXYRIBONUCLEIC ACID COMPRISING A BASE SEQUENCE ACID COMPRISING A BASE SEQUENCE CODING FOR THIS POLYPEPTIDE METHOD FOR PRODUCTING THIS POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION COMPRISING IT
A HUMAN PHYSIOLOGICALLY ACTIVE POLYPEPTIDE DEOXYRIBONUCLEIC ACID COMPRISING A BASE SEQUENCE ACID COMPRISING A BASE SEQUENCE CODING FOR THIS POLYPEPTIDE METHOD FOR PRODUCTING THIS POLYPEPTIDE AND PHARMACEUTICAL COMPOSITION COMPRISING IT
A human physiologically active polypeptide, human tumor necrosis factor( human TNF) comprising a specific amino acid sequence of 155 amino acid residues, the base sequence of the DNA coding for the human TNF has been determined using rabbit TNF CDNA, the human TNF can be advantageously produced on a large scale by recombinant DNA technique, the human TNF of the present invention has been found to be excellent in including necrosis of tumors with no toxic effect upon the normal tissues of the living body.
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