首页> 外国专利> NOVEL HETEROCYCLIC COMPOUND, MANUFACTURE AND REMEDY FOR ALLERGIC OR INFLAMMATORY DISEASE AND ENDOTOXIC AND TRAUMATICSHOCK SYMPTON

NOVEL HETEROCYCLIC COMPOUND, MANUFACTURE AND REMEDY FOR ALLERGIC OR INFLAMMATORY DISEASE AND ENDOTOXIC AND TRAUMATICSHOCK SYMPTON

机译:新颖的杂环化合物,变应性或发炎性疾病以及内毒素和创伤性抽搐症状的制造和补救

摘要

This invention provides a series of novel keto sulfones of formula I IMAGE in which the group =A- is selected from =C(Ra)- and =N- and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically acceptable salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.
机译:本发明提供了一系列新的式I 的酮基砜,其中基团= A-选自= C(Ra)-和= N-,其它基团具有以下说明书所定义的含义。式I化合物是白三烯拮抗剂。本发明还提供了式I化合物的药学上可接受的盐。含有式I化合物或其盐的药物组合物,用于治疗例如变应性或炎性疾病,或内毒素或外伤性休克病症;和制备式I化合物的方法,以及用于该制备的中间体。

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