首页> 外国专利> 100BROMSANDWICIN AND 100BROMISOSANDWICIN* THEIR MANUFACTURE* MANUFACTURE OF NBBQUATERNARY 100BROMSANDWICINN OR 100BROMSANDWICIN DERIVATIVE AND MEDICINAL COMPOSITION

100BROMSANDWICIN AND 100BROMISOSANDWICIN* THEIR MANUFACTURE* MANUFACTURE OF NBBQUATERNARY 100BROMSANDWICINN OR 100BROMSANDWICIN DERIVATIVE AND MEDICINAL COMPOSITION

机译：100BROMSANDWICIN和100BROMISOSANDWICIN *他们的制造* NBB第四季度100BROMSANDWICINN或100BROMSANDWICIN衍生物和药物组合物的制造

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摘要

10-bromosandwicine and 10-bromoisosandwicine and acid addition salts thereof are disclosed. There novel compounds possess valuable pharmacological properties e.g. heart rhythm regulatory properties. Furthermore they are valuable intermediates for the preparation of 10-brominated Nb-quaternary sandwicine derivatives which exhibit heart rhythm regulatory and adrenolytic properties. 10-bromosandwicine is prepared by brominating sandwicine and can subsequently be isomerized into 10-bromoisosandwicine.

机译：公开了10-溴山and碱和10-溴异山and碱及其酸加成盐。新型化合物具有有价值的药理特性，例如心律调节特性。此外，它们是制备具有心律调节和肾上腺皮质激素特性的10溴化Nb季沙wi衍生物的有价值的中间体。 10-溴甘草酸是通过溴化沙威辛来制备的，随后可异构化为10-溴异麦芽碱。

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公开/公告号JPS6241597B2

专利类型
公开/公告日1987-09-03

原文格式PDF
申请/专利权人 KALI CHEMIE PHARMA GMBH;
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申请/专利号JP19800142156
发明设计人 UORUFUGANGU KEERUBATSUHA;YOAHIMU UEEGENAA;
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申请日1980-10-13
分类号C07D461/00;A61K31/435;A61K31/437;A61K31/4375;A61K31/475;A61P9/00;A61P9/06;C07D209/00;C07D221/00;C07D471/22;
国家 JP
入库时间 2022-08-22 07:22:46

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