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ASTRAGALI RADIX SAPONIN, ISOLATION AND USE THEREOF
ASTRAGALI RADIX SAPONIN, ISOLATION AND USE THEREOF
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机译：黄芪总皂苷的分离纯化及其用途
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NEW MATERIAL:An astragaloside expressed by the formula. USE:An inhibitor for peroxylipid formation effective for preventing and treating arteriosclerosis. PREPARATION:Astraglic Radix is extracted with a lower alcohol, e.g. methanol, preferably while warming or heating, and the resultant extract is concentrated. The concentrate is then treated with an adsorbent, e.g. silica gel, and eluted to give a fraction, which is preferably subjected to reversed phase silica gel column chromatography [elution solvent is preferably methanol:water (5:4 5:1)]. The resultant saponin mixture is preferably dissolved in methanol, and diazomethane-ether solution is added thereto to convert the saponin into methyl ester. The resultant methyl ester is then separated by silica gel column chromatography [elution solvent is, e.g. n-butanol:ethyl acetate:water (4:1:5, upper layer)] and then treated with an alkali, e.g. 10% potassium hydroxide.
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