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foreign farnesilacetico acid derivatives

机译：外国法呢基乙酸衍生物

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摘要

Novel farnesylacetic acid ester derivatives containing an amine nitrogen in the alcohol residue thereof and represented by the following general formula exhibit high levels of antiulcerogenic activity and very low levels of toxicity: IMAGE wherein A is an alkylene radical containing at least 2 carbon atoms; R1 is H, alkyl, cycloalkyl, aryl, aralkyl or alkenyl; R2 and R3 are independently H, alkyl, aryl, aralkyl or alkenyl or one of R2 and R3 forms, together with A, a piperidine, pyrrolidine, tetrahydropyrimidine or piperazine ring which contains the nitrogen atom lying therebetween or R2 and R3 combine to form, together with the adjacent nitrogen atom, a piperazine ring; provided that the total number of carbon atoms contained in A, R1, R2 and R3 is at least 5.

机译：由以下通式表示的在其醇残基中含有胺氮的新型法呢基乙酸酯衍生物显示出高水平的抗溃疡活性和非常低的毒性：＜IMAGE＞其中A是含有至少2个碳原子的亚烷基。 R1为H，烷基，环烷基，芳基，芳烷基或烯基; R 2和R 3独立地为H，烷基，芳基，芳烷基或烯基，或R 2和R 3中的一个与A一起形成哌啶，吡咯烷，四氢嘧啶或哌嗪环，其间含有氮原子，或R 2和R 3结合形成，与相邻的氮原子一起形成哌嗪环;前提是A，R1，R2和R3中包含的碳原子总数至少为5。

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公开/公告号IT1126405B

专利类型
公开/公告日1986-05-21

原文格式PDF
申请/专利权人 KURARAY CO LTD;
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申请/专利号IT19790027613
发明设计人 OKABE SUSUMU;OMURA YOSHIAKI;NINAGAWA YOICHI;FUJITA YOSHIJI;
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申请日1979-11-27
分类号A61K31/215;A61K31/22;A61K31/445;A61P1/04;C07C67/00;C07C213/00;C07C219/08;C07C219/10;C07D211/22;C07D211/42;C07D211/46;C07D295/088;
国家 IT
入库时间 2022-08-22 07:39:12

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