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METHOD OF PREPARATION OF DERIVATIVES N7-amidino-SUBSTITUTES mitomycin C.
METHOD OF PREPARATION OF DERIVATIVES N7-amidino-SUBSTITUTES mitomycin C.
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机译:衍生物N7-ami基取代丝裂霉素C的制备方法。
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摘要
There is disclosed a process for the preparation of N7-amidino substituted mitomycin C derivatives. The process comprises reacting mitomycin C or an N1a substituted derivative thereof such as porfiromycin with a chloroformimidinium salt in a polar solvent at low temperature. This reaction is conducted in the presence of a tertiary amine. This process eliminates the need for a strong base such as NaH prior to addition of a chloroformimidinium salt.
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