首页> 外国专利> PROCESS FOR STABILIZING PHYSIOLOGICALLY ACTIVE MATERIAL PREPARED BY RECOMBINAT DNA TECHNIQUE, AND FOR PREPARING AQUEOUS SOLUTION OR POWDER CONTAINING THIS MATERIAL

PROCESS FOR STABILIZING PHYSIOLOGICALLY ACTIVE MATERIAL PREPARED BY RECOMBINAT DNA TECHNIQUE, AND FOR PREPARING AQUEOUS SOLUTION OR POWDER CONTAINING THIS MATERIAL

机译:稳定重组DNA技术制备的具有生理活性的材料以及制备包含该材料的水溶液或粉末的方法

摘要

A method for stabilizing a physiologically active substance produced by recombinant DNA technique, which comprises adding an albumin to an aqueous solution or powder containing the physiologically active substance, and a stable aqueous solution or powder which contains the physiologically active substance and an effective amount of an albumin, said physiologically active substance having cytotoxic activity against L-M cells and being capable of inducing hemorrhagic necrosis of transplanted Meth A sarcoma in the BALB/c mouse. The aqueous solution or powder containing the physiologically active substance can be stored for a prolonged period of time without losing its activity, and is stable on freezing, thawing, lyophilization or the like.
机译:一种稳定通过重组DNA技术生产的生理活性物质的方法,该方法包括将白蛋白添加到含有该生理活性物质的水溶液或粉末中,以及一种稳定的,包含该生理活性物质和有效量的维生素A的水溶液或粉末中。白蛋白,所述生理活性物质对LM细胞具有细胞毒活性,并且能够在BALB / c小鼠中诱导移植的甲乙肉瘤的出血性坏死。含有生理活性物质的水溶液或粉末可以长时间保存而不失去其活性,并且在冷冻,解冻,冻干等方面稳定。

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