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AQUEOUS CRYSTAL SUSPENSION OF STEROID GLYCOBENZOATE AND 17-TERTIARY STEROID GLYCOESTER
AQUEOUS CRYSTAL SUSPENSION OF STEROID GLYCOBENZOATE AND 17-TERTIARY STEROID GLYCOESTER
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机译：苯乙酸酯类固醇和17-三元甾醇类缩水甘油的水悬浮液
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摘要
An aqueous crystalline suspension of a 17-tertiary steroid glycoester contains a compound of Formula I IMAGE (I) wherein X is two hydrogen atoms or an oxygen atom, Y is two hydrogen atoms or a methylene group, R1 is hydrogen or methyl, Z is hydroxy or -O-CO-R2 R2 is methyl or phenyl, and IMAGE in the following fractions: 0-30% by weight of a particle size of 3-15 mu m, 40-90% by weight of a particle size of 15-60 mu m, and 20-60% by weight of a particle size of 30-100 mu m. Upon a one-time intramuscular injection of 30-75 mg of steroid glycoester as an aqueous crystalline suspension, a steroid level is achieved in the plasma which, over a period of 4 weeks, is adequately high and shows a uniform course.
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机译：17-叔类固醇糖酯的结晶水悬浮液含有式I化合物（I），其中X为两个氢原子或一个氧原子，Y为两个氢原子或一个亚甲基，R1为氢或甲基， Z为羟基或-O-CO-R 2 R 2为甲基或苯基，并且具有以下比例：3-30μm的粒径为0-30重量％，a为40-90重量％粒度为15-60微米，粒度的20-60％（重量）为30-100微米。一次肌肉内注射30-75 mg类固醇糖脂为水性结晶悬浮液后，血浆中的类固醇水平达到较高，在4周内足够高并显示出均匀的进程。
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