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首页> 外国专利> 5-PYRIMIDINECARBOXAMIDE OR THIOCARBOXAMIDE, A PHARMACEUTICAL COMPOSITION FOR INDUCING THE REGRESSION OF LEUKEMIA AND THE INHIBITION OF THE GROWTH OF TUMORS CONTAINING SAME, PROCESS FOR PRODUCING 5-PYRIMIDINECARBOXAMIDE OR THIOCARBOXAMIDE, AND METHOD FOR INDUCING THE REGRESSION OF LEUKEMIA AND THE INHIBITION OF THE GROWTH OF TUMORS BY USING IT

5-PYRIMIDINECARBOXAMIDE OR THIOCARBOXAMIDE, A PHARMACEUTICAL COMPOSITION FOR INDUCING THE REGRESSION OF LEUKEMIA AND THE INHIBITION OF THE GROWTH OF TUMORS CONTAINING SAME, PROCESS FOR PRODUCING 5-PYRIMIDINECARBOXAMIDE OR THIOCARBOXAMIDE, AND METHOD FOR INDUCING THE REGRESSION OF LEUKEMIA AND THE INHIBITION OF THE GROWTH OF TUMORS BY USING IT

机译：5-嘧啶碳酰胺或硫代羧酰胺，用于诱导白血病的复发和抑制含有相同肿瘤的药物的药物组合物，制备5-嘧啶碳酰胺或硫代羧酰胺的制备方法，以及其诱导方法通过使用它的肿瘤

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摘要

The invention relates to a 5-pyrimidinecarboxamide or thiocarboxamide. According to the invention, it has the following formula: ## STR2 ## AND R IS INDEPENDENTLY HYDROGEN; AN ALKYL, ARYL, ARALCYL, ALLYL, ARALKENYL OR ARALKYNYL, ALKYLYL OR ALKYNYL FRAGMENTS HAVE 1 TO 6 ATOMES OF CARBON, OR A RESIDUE OF CARBOHYDRATE; / P P R IS HYDROGEN , CC or ARYL ALKYL; R, PHENYL, NAPHTHYL, BENZYL, NAPHTYLMETHYL, THIENYL, THIENYLMETHYL OR PYRIDYL; OR PHENYL, NAPHTHYL, BENZYL, NAPHTYLMETHYL, THIENYL, THIENYLMETHYL OR PYRIDYL SUBSTITUTED BY ONE OR MORE OF THE FOLLOWING GROUPS: HYDROXY; HALO; ALKYL, ALCOXY, ALKYLTHIO, HALOALCOYL OR HALOALCOXY HAVING 1 TO 4 ATOMES OF CARBON; CARBOXY; ALCOXYCARBONYL HAVING 2 TO 5 ATOMES OF CARBON; NITRO; CYANO; ARYL; ARYLOXY; arylthio; BENZYL; benzyloxy; naphthylmethyl; naphthylmethyloxy; thienyl; OR THIENYLMETHYLE; / P P W IS OXYGEN OR SULFUR; / P P Y AND Z ARE EACH INDEPENDENT OF OXYGEN, SULFUR OR SELENIUM; AND THEIR ACID-ACCEPTABLE ACID-ADDING SALTS IN PHARMACY. / P P THE INVENTION APPLIES IN PARTICULAR TO THE TREATMENT OF LEUKEMIA AND TUMORS. / P
机译：本发明涉及5-嘧啶羧酰胺或硫代羧酰胺。根据本发明，它具有下式：## STR2 ##和R独立地为氢;烷基，芳基，芳基，烯丙基，芳烯基或芳炔基，烷基或炔基片段具有1-6个碳原子或碳酸盐残基;

R是氢，CC或芳基烷基; R，苯基，萘基，苄基，萘甲基，噻吩基，噻吩甲基或吡啶基;或被一个或多个以下基团取代的苯基，萘基，苄基，萘甲基，噻吩基，噻吩基甲基或吡啶基：羟基;光环;具有1-4个碳原子的烷基，烷氧基，烷基硫基，卤代醇基或卤代代醇;羧;烷氧基羰基具有2至5个碳原子;硝基;矢野; ARYL; ARYLOXY;芳硫基苯;苄氧基;萘甲基;萘甲氧基;噻吩基或三甲基;

W是氧气或硫;

Y和Z分别是氧，硫或硒的独立元素;及其在药房中可以接受的酸添加盐。

本发明特别适用于白血病和肿瘤的治疗。

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