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METHOD FOR THE DETERMINATION OF LIABILITY IN HUMAN INDIVIDUALS TO DEVELOP NIDDM AND/OR ATHEROSCLEROSIS
METHOD FOR THE DETERMINATION OF LIABILITY IN HUMAN INDIVIDUALS TO DEVELOP NIDDM AND/OR ATHEROSCLEROSIS
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机译：确定人类发展NIDDM和/或动脉粥样硬化的责任的方法
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摘要
14A b s t r a c tLiability in human individuals to develop non-insulin-dependent diabetes mellitus (NIDDM) and/or athero-sclerosis is determined by restriction enzyme mappingof DNA from a human individual using a probe selectedfrom the group consisting of(i) cDNA complementary to the mRNA coding forthe human insulin,(ii) human genomic DNA containing the actual insulingene,(iii) DNA sequences of human genomic DNA locatedwithin 20 x 106 base pairs from the insulingene in either direction,and examining the distribution of DNA fragments forthe appearance of insertion sequences of approximately1600 to 2300 base pairs (U alleles) the occurence ofwhich indicates a liability for said individual todevelop elevated blood glucose concentrations and/oratherosclerosis and in homozygous form a liability todevelop NIDDM.
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机译：14b人类发展非胰岛素的责任依赖型糖尿病（NIDDM）和/或动脉粥样硬化通过限制性酶切图谱确定硬化人类使用选定的探针提取DNA来自于（i）与编码人类胰岛素（ii）含有实际胰岛素的人类基因组DNA基因，（iii）位于人类基因组DNA的DNA序列距胰岛素20 x 106个碱基对以内任一方向的基因并检查DNA片段的分布大约插入序列的出现1600至2300个碱基对（U等位基因）的发生表明该个人有责任血糖升高和/或动脉粥样硬化和纯合形成开发NIDDM。
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