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Process for increasing glycine levels in the brain and spinal cord

机译:增加大脑和脊髓中甘氨酸水平的过程

摘要

The level of glycine in the brain and in the spinal cord is regulated by administering a neutral amino acid composition to a human wherein increased or decreased brain and spinal cord levels of glycine is effected when the composition contains increased or decreased amounts of threonine or a precursor of L-threonine. The neutral amino acid composition can be administered alone or concomitantly with a drug which either has the undesirable side effect of suppressing glycine-mediated neurotransmission or whose therapeutic efficacy is enhanced by increasing glycinergic neurotransmission.
机译:通过向人施用中性氨基酸组合物来调节大脑和脊髓中甘氨酸的水平,其中当组合物包含增加或减少量的苏氨酸或前体时,会导致大脑和脊髓中甘氨酸水平的增加或减少。苏氨酸。中性氨基酸组合物可以单独地或与具有抑制甘氨酸介导的神经传递的不良副作用或通过增加甘氨酸能神经传递而增强治疗功效的药物一起给药。

著录项

  • 公开/公告号US4397866A

    专利类型

  • 公开/公告日1983-08-09

    原文格式PDF

  • 申请/专利权人 MASSACHUSETTS INSTITUTE OF TECHNOLOGY;

    申请/专利号US19790036925

  • 发明设计人 RICHARD J. WURTMAN;

    申请日1979-05-07

  • 分类号A61K31/195;

  • 国家 US

  • 入库时间 2022-08-22 09:49:28

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