首页>
外国专利>
The novel compounds belonging to the family of benzoyl - and - hydroxybenzyl - phenyl - osides, their process of preparation and their application of international application no.
The novel compounds belonging to the family of benzoyl - and - hydroxybenzyl - phenyl - osides, their process of preparation and their application of international application no.
展开▼
机译：属于苯甲酰基-和-羟基苄基-苯基-核苷家族的新型化合物，其制备方法及其在国际申请No.
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to the benzoyl- and alpha -hydroxybenzyl-phenyl-oside derivatives of general formula: IMAGE (I) [in which Z is CO or CHOH, X1, X2, X3, X4 and X5, which are identical or different, each represent an atom of hydrogen, an atom of halogen, an alkyl group with 1 to 4 carbon atoms, an alkyl group with 1 to 4 carbon atoms substituted by one or more atoms of halogen, an OH group, an alkoxy group with 1 to 4 carbon atoms, an alkoxy group with 1 to 4 carbon atoms, substituted by one or more atoms of halogen, a nitro group, a cyano group, a thiocyano group, an isothiocyano group, a NR'R'' group (where R' and R'', identical or different, each represent an atom of hydrogen or an alkyl group with 1 to 4 carbon atoms) X1 being able, in addition, to represent an -NH-CS-O-CH3 group or an -O-C(CH3)2 CO2-R''' group (where R''' is an alkyl group with 1 to 4 carbon atoms and, preferably, an isopropyl group); and R represents a radical ose (the hydroxyl and amine functions of the radical ose being able to be substituted by acyl, alkyl or sulfate groups)], and to their diastereoisomers. It also relates to the method for preparing these derivatives and to their application in therapeutics.
展开▼
机译：本发明涉及通式为：[IMAGE]（I）的苯甲酰基-和α-羟基苄基-苯基-侧基的衍生物[其中Z是CO或CHOH，X1，X2，X3，X4和X5是相同的或不同的是，每个代表氢原子，卤素原子，碳数为1-4的烷基，被一个或多个卤素原子取代的碳数为1-4的烷基，OH，烷氧基和1-4个碳原子，一个1-4个碳原子的烷氧基，被一个或多个卤素，硝基，氰基，硫代氰基，异硫氰基，NR'R''基团取代（其中R′和R″相同或不同，各自代表氢原子或具有1-4个碳原子的烷基）X1还能够代表-NH-CS-O-CH3基团或- OC（CH 3）2 CO 2 -R'基（其中R'是碳数为1-4的烷基，优选为异丙基）; R表示自由基糖（该自由基糖的羟基和胺官能团可以被酰基，烷基或硫酸根取代）]及其非对映异构体。它还涉及制备这些衍生物的方法及其在治疗中的应用。
展开▼
