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New derivatives of 1,2,4 -, their process of manufacture and their application as a antifecondants agents and to pharmaceutical compositions

机译:1,2,4-的新衍生物,其制备方法及其在抗抑con剂中的应用以及在药物组合物中的应用

摘要

Novel 1,2,4-triazole derivatives are described having the following formula CHEM wherein R represents hydrogen or methyl, R1 stands for hydrogen or (C1-C4)alkyl, or R and R1 taken together may represent a further bond between the carbon atom and the oxygen atom, R2 and R4 each independently, represent hydrogen, chloro, fluoro, bromo, (C1-C4)alkyl or (C1-C4)alkoxy, R3 stands for (C1-C4)alkyl, (C1-C4)alkoxy, allyloxy propargyloxy, trifluoromethyl, phenyl, chloro, fluoro, bromo or dimethylamino or R3 and R4 taken together may represent a methylenedioxy group. Also described is a process for their manufacture. Use of the novel compounds as antireproductive agents and pharmaceutical compositions containing them as active ingredient are also claimed.
机译:描述了具有下式的新型1,2,4-三唑衍生物,其中R代表氢或甲基,R1代表氢或(C1-C4)烷基,或R和R1一起可以代表碳原子和氧原子,R 2和R 4各自独立地表示氢,氯,氟,溴,(C 1 -C 4)烷基或(C 1 -C 4)烷氧基,R 3代表(C 1 -C 4)烷基,(C 1 -C 4)烷氧基,烯丙氧基炔丙基氧基,三氟甲基,苯基,氯,氟,溴或二甲基氨基,或R 3和R 4一起可以表示亚甲基二氧基。还描述了其制造过程。还要求保护所述新型化合物作为抗生殖剂的用途和包含它们作为活性成分的药物组合物。

著录项

  • 公开/公告号FR2440363B1

    专利类型

  • 公开/公告日1983-10-28

    原文格式PDF

  • 申请/专利权人 GRUPPO LEPETIT;

    申请/专利号FR19790026821

  • 发明设计人

    申请日1979-10-30

  • 分类号C07D249/08;C07D405/04;A61K31/41;

  • 国家 FR

  • 入库时间 2022-08-22 10:01:51

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