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Process for preparing inclusion complexes of steroids poorly soluble in water with cyclodextrin.
Process for preparing inclusion complexes of steroids poorly soluble in water with cyclodextrin.
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机译：与环糊精一起制备难溶于水的类固醇包合物的方法。
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摘要
The title complexes have 3-100 times the water-solubility of the uncomplexed steroids, e.g. spironolactone, nortestosterone, methyltestosterone, androst-4-ene- 3,17-dione, progesterone, Reichstein S, Reichstein S aceate, 16-methyl- Reichstein S, Hydrocortisone, estrone, dexamethasone, prednisolone, triamcinolone, pregnenetriolone triacetate. Pharmaceutical compositions containing the title complexes are free from the nephrotoxic effects of the corresponding alpha - and beta -cyclodextrin complexes owing to the faster enzymatic decomposition of delta -cyclodextrin.
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机译：标题配合物的水溶性是未配合的类固醇的3-100倍，例如螺内酯，去甲睾丸激素，甲基睾丸激素，androst-4-ene-3,17-dione，黄体酮，Reichstein S，Reichstein S aceate，16-甲基-Reichstein S，氢化可的松，雌酮，地塞米松，泼尼松龙，曲安西龙，孕烯醇酮三乙酸酯。由于δ-环糊精的酶促分解更快，因此含有标题复合物的药物组合物没有相应的α-和β-环糊精复合物的肾毒性作用。
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