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PROCESS FOR PREPARING THE ACTAPLANINANTIBIOTIC COMPLEX A-4696 WITH FACTORS B DEEP 1, B DEEP 2, B DEEP 3, C DEEP 1 DEEP A, C DEEP 3 AND E LOW 1
PROCESS FOR PREPARING THE ACTAPLANINANTIBIOTIC COMPLEX A-4696 WITH FACTORS B DEEP 1, B DEEP 2, B DEEP 3, C DEEP 1 DEEP A, C DEEP 3 AND E LOW 1
Antibiotic A-4696 factors B1, B2, B3, C1a, C3, and E1 are isolated from antibiotic A-4696, the latter being produced by Actinoplanes missouriensis strains ATCC 31680, ATCC 31682, and ATCC 31683 under submerged aerobic conditions in a culture medium and isolated from the fermentation broth by absorption on an ion exchange resin and eluted therefrom at pH 10.5 with sodium hydroxide. The novel factors are separated by thin layer chromatography and high pressure liquid chromatography and have antimicrobial and growth promotant activity.
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